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Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture.

Brain, behavior, and immunity - 1 Jan 2025

Lin Yi-Wen, Cheng Szu-Wei, Liu Wen-Chun, Zailani Halliru, Wu Suet-Kei, Hung Mien-Chie, Su Kuan-Pin

Abstract excerpt

The comorbidity of obesity and depression has major public health impacts, highlighting the need to understand their shared mechanisms. This study explored the connection between obesity and depression through the transient receptor potential V1 (TRPV1) signaling pathway, using obese/depressed murine models and clinical data. Mice fed a high-fat diet showed altered TRPV1 pathway expression in brain regions of the...

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PMID: 39454693
DOI: 10.1016/j.bbi.2024.10.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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