Article
Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.
Arthritis and rheumatism - 1 Dec 2013
Miller Frederick W, Cooper Robert G, Vencovský Jiří, Rider Lisa G, Danko Katalin, Wedderburn Lucy R, Lundberg Ingrid E, Pachman Lauren M, Reed Ann M, Ytterberg Steven R, Padyukov Leonid, Selva-O'Callaghan Albert, Radstake Timothy R D J, Isenberg David A, Chinoy Hector, Ollier William E R, O'Hanlon Terrance P, Peng Bo, Lee Annette, Lamb Janine A, Chen Wei, Amos Christopher I, Gregersen Peter K
Abstract excerpt
OBJECTIVE: To identify new genetic associations with juvenile and adult dermatomyositis (DM). METHODS: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex...
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