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Article

Concordance of ctDNA and tissue genomic profiling in advanced biliary tract cancer.

Journal of hepatology - 1 Apr 2025

Hwang Sohyun, Woo Seonjeong, Kang Beodeul, Kang Haeyoun, Kim Jung Sun, Lee Sung Hwan, Kwon Chang Il, Kyung Dong Soo, Kim Hwang-Phill, Kim Gwangil, Kim Chan, Chon Hong Jae

Abstract excerpt

BACKGROUND & AIMS: Recent advances in molecular profiling have enabled the identification of potential therapeutic targets for biliary tract cancer (BTC). However, in patients with BTC, molecular profiling is hindered by challenges in obtaining adequate tissue samples. Circulating tumor DNA (ctDNA) may offer an alternative to tissue-based analysis. Herein, we aimed to assess the concordance between ctDNA and...

Read the complete abstract on PubMed

Topics

Humans
Circulating Tumor DNA
Female
Male
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biliary Tract Neoplasms

High-Throughput Nucleotide Sequencing

Liquid Biopsy

Biomarkers, Tumor

Adult

Mutation

Aged, 80 and over

Prognosis

Source

Identifiers

PMID: 39442892
DOI: 10.1016/j.jhep.2024.10.020

Genes

BTC
FGFR2
BRCA1
ERBB2
IDH1
IMPACT
MET
PIK3CA
TNS1

Provenance

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