Article
The clinical landscape of cell-free DNA alterations in 1671 patients with advanced biliary tract cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2022
Berchuck J E, Facchinetti F, DiToro D F, Baiev I, Majeed U, Reyes S, Chen C, Zhang K, Sharman R, Uson Junior P L S, Maurer J, Shroff R T, Pritchard C C, Wu M-J, Catenacci D V T, Javle M, Friboulet L, Hollebecque A, Bardeesy N, Zhu A X, Lennerz J K, Tan B, Borad M, Parikh A R, Kiedrowski L A, Kelley R K, Mody K, Juric D, Goyal L
Abstract excerpt
BACKGROUND: Targeted therapies have transformed clinical management of advanced biliary tract cancer (BTC). Cell-free DNA (cfDNA) analysis is an attractive approach for cancer genomic profiling that overcomes many limitations of traditional tissue-based analysis. We examined cfDNA as a tool to inform clinical management of patients with advanced BTC and generate novel insights into BTC tumor biology. PATIENTS AND...
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