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Insights Into the Molecular Interactions of MIC2 and M2AP: Role of TSR6 and Conservation Across Species.

Proteins - 1 Mar 2025

Xia Xu, Du Chenqiang, Wang Yang, Song Gaojie

Abstract excerpt

Microneme protein 2 (MIC2) and its associated protein M2AP are pivotal for the gliding motility and host cell invasion by Toxoplasma gondii. In our prior work, we showed that M2AP binds specifically to the sixth TSR domain of MIC2, with this interaction mediated dominantly by the hotspot residue H620 situated at the center of TSR6. To delve deeper into the functional significance of H620 and explore the dynamic...

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PMID: 39435576
DOI: 10.1002/prot.26758

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