Article
A method for determining potential parental contamination: linkage disequilibrium-based log-likelihood ratio analysis for IVF-PGT.
Reproductive biology and endocrinology : RB&E - 21 Oct 2024
Bo Le, Dong Fangfang, Wu Zhinan, Zhou Anwen, Zhang Yulan, Kong Lingyin, Zhan Lei, Lu Naru, Qi Lina, Sun Tingting, Liang Bo, Mao Caiping
Abstract excerpt
BACKGROUND: At present, embryologists are attempting to use conventional in vitro fertilization (cIVF) as an alternative to intracytoplasmic sperm injection (ICSI) for preimplantation genetic testing (PGT). However, the potential parental contamination origin of sperm cells and cumulus cells is considered the main limiting factor in the inability of cIVF embryos to undergo PGT. METHODS: In this study, we...
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