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Investigating DNA contamination affecting embryo biopsy specimens taken for PGT-A: Incidence and impact on the accuracy of chromosomal analysis.

Reproductive biomedicine online - 1 Aug 2026

Clark Georgina, Babariya Dhruti, Kilbee Medley, Fernández Marcos Elena, Haj Ali Ayman, Ceban Vasile, Capalbo Antonio, Wells Dagan

Abstract excerpt

RESEARCH QUESTION: What is the prevalence of DNA contamination in embryo biopsy samples taken for preimplantation genetic testing for aneuploidy (PGT-A), and how often might contamination lead to incorrect interpretation of results? DESIGN: A retrospective study of 57,292 clinical PGT-A samples from 32 IVF clinics was carried out to determine the frequency of DNA contamination affecting trophectoderm biopsy...

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PMID: 42167074
DOI: 10.1016/j.rbmo.2026.105637

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