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Article

A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data.

Genome biology - 21 Oct 2024

Mustafa Rima, Mens Michelle M J, van Hilten Arno, Huang Jian, Roshchupkin Gennady, Huan Tianxiao, Broer Linda, van Meurs Joyce B J, Elliott Paul, Levy Daniel, Ikram M Arfan, Evangelou Marina, Dehghan Abbas, Ghanbari Mohsen

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact disease risk and have potential as disease biomarkers. Exploring the genetic regulation of miRNAs may yield new insights into their important role in governing gene expression and disease mechanisms. RESULTS: We present genome-wide association...

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Identifiers

PMID: 39434104
DOI: 10.1186/s13059-024-03420-6
PMCID: PMC11492503

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