Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease.

doi:10.1016/j.jchf.2024.08.011

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Article

Genetic Landscape of Patients With Dilated Cardiomyopathy and a Systemic Immune-Mediated Disease.

JACC. Heart failure - 1 Jan 2025

Stroeks Sophie L V M, Henkens Michiel T H M, Dominguez Fernando, Merlo Marco, Hellebrekers Debby M E I, Gonzalez-Lopez Esther, Dal Ferro Matteo, Ochoa Juan Pablo, Venturelli Francesco, Claes Godelieve R F, Venner Max F G H M, Krapels Ingrid P C, Vanhoutte Els K, van Paassen Pieter, van den Wijngaard Arthur, Sikking Maurits A, van Leeuwen Rick, Abdul Hamid Myrurgia, Li Xiaofei, Brunner Han G, Sinagra Gianfranco, Garcia-Pavia Pablo, Heymans Stephane R B, Verdonschot Job A J

Abstract excerpt

BACKGROUND: Systemic immune-mediated diseases (SIDs) are a well-known cause of dilated cardiomyopathy (DCM), a cardiac phenotype influenced by genetic predispositions and environmental factors. OBJECTIVES: This study sought to examine if an underlying genetic predisposition is present in patients with DCM and SID. METHODS: Genotyped DCM-SID patients (n = 183) were enrolled at 3 European centers. Genetic variants...

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PMID: 39425739
DOI: 10.1016/j.jchf.2024.08.011

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