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Article

Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer.

International journal of molecular sciences - 24 Sept 2024

Villacis Rolando André Rios, Côrtes Luiza, Basso Tatiane Ramos, do Canto Luisa Matos, Souza Jeferson Santos, Aagaard Mads Malik, da Cruz Formiga Maria Nirvana, Aguiar Samuel, Achatz Maria Isabel, Rogatto Silvia Regina

Abstract excerpt

A hereditary component of breast (BC) and colorectal cancer (CRC) has been described in approximately one-third of these tumor types. BC patients have an increased risk of developing CRC as a second primary tumor and vice versa. Germline genomic variants (NextSeq550, Illumina) were investigated in 24 unrelated BC and/or CRC patients and 7 relatives from 3 index patients. Fifty-six pathogenic or likely pathogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39408606
DOI: 10.3390/ijms251910275
PMCID: PMC11476855

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