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Genetic Variations in the NRF2 Microsatellite Contribute to the Regulation of Bovine Sperm-Borne Antioxidant Capacity.

Cells - 24 Sept 2024

Anwar Khurshaid, Thaller Georg, Saeed-Zidane Mohammed

Abstract excerpt

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor protein-coding gene, considered a master regulator of the cellular stress response. The genetic variations of the NRF2 could influence its transcriptional profile and, subsequently, the stress resilience in all cell types, including sperm cells. Therefore, the sperm-borne antioxidants abundance in association with the genetic variation...

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PMID: 39404365
DOI: 10.3390/cells13191601
PMCID: PMC11482559

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