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Article

Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2012

Yu Bolan, Lin Huanlan, Yang Lixia, Chen Kang, Luo Haihua, Liu Jianqiao, Gao Xingcheng, Xia Xuefeng, Huang Zhaofeng

Abstract excerpt

Defective spermatogenesis, which severely impairs male fertility, can be caused by excessive reactive oxygen species (ROS). Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates transcription of genes encoding enzymes important for protection against ROS. In human seminal plasma and sperma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22648520
DOI: 10.1007/s00109-012-0914-z

Genes

GSTM1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22648520-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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