Article
Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion.
Frontiers in immunology - 1 Jan 2019
Wu Yingcheng, Tao Baorui, Zhang Tianyang, Fan Yihui, Mao Renfang
Abstract excerpt
Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved. Here, we systematically analyze the core genes of the circadian clock (CLOCK, ARNTL, ARNTL2, NPAS2, NR1D1, NR1D2, CRY1, CRY2, RORA, RORB, RORC, PER1, PER2, and PER3) across a broad range of cancers. To our surprise, core negative regulators (PER1, PER2,...
Topics
- Circadian Clocks
- Clonal Anergy
- Computational Biology
- DNA Copy Number Variations
- Databases, Genetic
- Disease Susceptibility
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genetic Heterogeneity
- Genetic Predisposition to Disease