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Article

Effects of selection stringency on the outcomes of directed evolution.

PloS one - 1 Jan 2024

Alpay Berk A, Desai Michael M

Abstract excerpt

Directed evolution makes mutant lineages compete in climbing complicated sequence-function landscapes. Given this underlying complexity it is unclear how selection stringency, a ubiquitous parameter of directed evolution, impacts the outcome. Here we approach this question in terms of the fitnesses of the candidate variants at each round and the heterogeneity of their distributions of fitness effects. We show...

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Identifiers

PMID: 39401192
DOI: 10.1371/journal.pone.0311438
PMCID: PMC11472920

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