AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular.

doi:10.1182/bloodadvances.2024013648

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AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular.

Blood advances - 14 Jan 2025

Castaño-Díez Sandra, López-Guerra Mònica, Zugasti Inés, Calvo Xavier, Schulz Felicitas Isabel, Avendaño Alejandro, Mora Elvira, Falantes José, Azaceta Gemma, Ibáñez Mariam, Chen Tzu, Notario Cristina, Amer Neus, Palomo Laura, Pomares Helena, Vila Jordi, Bernal Del Castillo Teresa, Jiménez-Vicente Carlos, Esteban Daniel, Guijarro Francesca, Álamo José, Cortés-Bullich Albert, Torrecillas-Mayayo Víctor, Triguero Ana, Mont-de Torres Lucía, Carcelero Ester, Cardús Aina, Germing Ulrich, Betz Beate, Rozman Maria, Arenillas Leonor, Zamora Lurdes, Díez-Campelo María, Xicoy Blanca, Esteve Jordi, Díaz-Beyá Marina

Abstract excerpt

ABSTRACT: Mutations commonly associated with acute myeloid leukemia (AML), such as CEBPA, FLT3, IDH1/2, and NPM1, are rarely found in chronic myelomonocytic leukemia (CMML), and their prognostic significance in CMML has not been clearly identified. In 127 patients with CMML, we have retrospectively analyzed next-generation sequencing and polymerase chain reaction data from bone marrow samples collected at the...

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PMID: 39388660
DOI: 10.1182/bloodadvances.2024013648

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