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Ursolic acid interaction with transcription factors BRAF, V600E, and V600K: a computational approach towards new potential melanoma treatments.

Journal of molecular modeling - 10 Oct 2024

Aguilera-Durán Giovanny, Hernández-Castro Stephanie, Loera-García Brenda V, Rivera-Vargas Alex, Alvarez-Baltazar J M, Cuevas-Flores Ma Del Refugio, Romo-Mancillas Antonio

Abstract excerpt

CONTEXT: Melanoma is one of the cancers with the highest mortality rate for its ability to metastasize. Several targets have undergone investigation for the development of drugs against this pathology. One of the main targets is the kinase BRAF (RAF, rapidly accelerated fibrosarcoma). The most common mutation in melanoma is BRAFV600E and has been reported in 50-90% of patients with melanoma. Due to the relevance...

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PMID: 39387972
DOI: 10.1007/s00894-024-06165-y

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