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Docking Analysis on Mutated Proteins in Cardio-Facio-Cutaneous Syndrome: Amentoflavone E Hypericin Potential Role

2024-09-03

Abstract excerpt

Cardiofaciocutaneous (CFC) syndrome, linked to mutations in genes including KRAS, BRAF, MEK1, and MEK2, leads to dysregulated RAS-MAPK signaling with limited therapeutic options. This study utilized molecular docking simulations to screen natural compounds against mutated KRAS, BRAF, MEK1, and MEK2 structures. Promising candidates such as Amentoflavone and Hypericin displayed strong binding affinities and favorabl...

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Identifiers and source

Literature Corpus work
237865e4-5931-5871-8c83-debd0dad8e4c
DOI
10.20944/preprints202409.0140.v1
Open publication

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Docking Analysis on Mutated Proteins in Cardio-Facio-Cutaneous Syndrome: Amentoflavone E Hypericin Potential RoleDOI 10.20944/preprints202409.0140.v1
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