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Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements

9 Oct 2024

Abstract excerpt

CRISPR-based genome editing of pseudogene-associated disorders, such as p47phox-deficient chronic granulomatous disease (p47 CGD), is challenged by chromosomal rearrangements due to presence of multiple targets. We report that interactions between highly homologous sequences that are localized on the same chromosome contribute substantially to post-editing chromosomal rearrangements. We successfully employed...

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PMID: 39384978
DOI: 10.1038/s42003-024-06959-z

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