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Article

LMNA Co-Regulated Gene Expression as a Suitable Readout after Precise Gene Correction.

International journal of molecular sciences - 8 Dec 2022

Wang Haicui, Krause Anne, Escobar Helena, Müthel Stefanie, Metzler Eric, Spuler Simone

Abstract excerpt

LMNA-related muscular dystrophy is an autosomal-dominant progressive disorder caused by mutations in LMNA. LMNA missense mutations are becoming correctable with CRISPR/Cas9-derived tools. Evaluating the functional recovery of LMNA after gene editing bears challenges as there is no reported direct loss of function of lamin A/C proteins in patient-derived cells. The proteins encoded by LMNA are lamins A/C,...

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Identifiers

PMID: 36555163
DOI: 10.3390/ijms232415525
PMCID: PMC9778678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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