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Genomic surveillance reveals a dengue 2 virus epidemic lineage with a marked decrease in sensitivity to Mosnodenvir.

Nature communications - 9 Oct 2024

Bouzidi Hawa Sophia, Sen Selin, Piorkowski Géraldine, Pezzi Laura, Ayhan Nazli, Fontaine Albin, Canivez Thomas, Geulen Manon, Amaral Rayane, Grard Gilda, Durand Guillaume André, de Lamballerie Xavier, Touret Franck, Klitting Raphaëlle

Abstract excerpt

Dengue fever is the most important arbovirosis for public health, with more than 5 million cases worldwide in 2023. Mosnodenvir is the first anti-dengue compound with very high preclinical pan-serotype activity, currently undergoing phase 2 clinical evaluation. Here, by analyzing dengue virus (DENV) genomes from the 2023-2024 epidemic in the French Caribbean Islands, we show that they all exhibit mutation...

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Identifiers

PMID: 39384752
DOI: 10.1038/s41467-024-52819-z
PMCID: PMC11464713

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