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Article

Influence of CCR5 and CCR2 genetic variants in the resistance/susceptibility to HIV in serodiscordant couples from Colombia.

AIDS research and human retroviruses - 1 Dec 2013

Zapata Wildeman, Aguilar-Jiménez Wbeimar, Pineda-Trujillo Nicolás, Rojas Winston, Estrada Hernando, Rugeles María T

Abstract excerpt

The main genetic factor related to HIV-1 resistance is the CCR5-Δ32 mutation; however, the homozygous genotype is uncommon. The CCR5-Δ32 mutation along with single nucleotide polymorphisms (SNPs) in the CCR5 promoter and the CCR2-V64I mutation have been included in seven human haplogroups (HH) previously associated with resistance/susceptibility to HIV-1 infection and different rates of AIDS progression. Here, we...

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Source

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Identifiers

PMID: 24098976
DOI: 10.1089/aid.2012.0299
PMCID: PMC3848445

Genes

CCR5
CCR2

Variants

Provenance

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