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Article

Clinical Utility of Genetic Variants in PNPLA3 and TM6SF2 to Predict Liver-Related Events in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2025

Seko Yuya, Yamaguchi Kanji, Shima Toshihide, Iwaki Michihiro, Takahashi Hirokazu, Kawanaka Miwa, Tanaka Saiyu, Mitsumoto Yasuhide, Yoneda Masato, Nakajima Atsushi, Okanoue Takeshi, Itoh Yoshito

Abstract excerpt

BACKGROUND AND AIMS: Fibrosis-4 (FIB-4) index and genetic polymorphisms have been used in assessing the risk of liver-related events (LRE) in metabolic dysfunction-associated steatotic liver disease (MASLD). To establish a more efficient prediction strategy for LRE, we investigated a combined approach that uses the FIB-4 index and genetic polymorphisms. METHODS: We enrolled 1304 Japanese patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39373247
DOI: 10.1111/liv.16124

Genes

PNPLA3
TM6SF2
GCKR
MBOAT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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