Article
Evidence of two distinct functionally specialized fibroblast lineages in breast stroma.
Breast cancer research : BCR - 3 Nov 2016
Morsing Mikkel, Klitgaard Marie Christine, Jafari Abbas, Villadsen René, Kassem Moustapha, Petersen Ole William, Rønnov-Jessen Lone
Abstract excerpt
BACKGROUND: The terminal duct lobular unit (TDLU) is the most dynamic structure in the human breast and the putative site of origin of human breast cancer. Although stromal cells contribute to a specialized microenvironment in many organs, this component remains largely understudied in the human breast. We here demonstrate the impact on epithelium of two lineages of breast stromal fibroblasts, one of which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.