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Article

DAXX is associated with early recurrence of pancreatic neuroendocrine tumors after R0 resection.

Surgery - 1 Jan 2025

Greenspun Benjamin C, Foshag Amanda, Tumati Abhinay, Marshall Teagan, Xue Dongxiang, Yang Liuliu, Chen Shuibing, Zarnegar Rasa, Fahey Thomas J, Finnerty Brendan M

Abstract excerpt

INTRODUCTION: ATRX, DAXX, MEN1, and PTEN mutations are proposed drivers of pancreatic neuroendocrine tumor tumorigenesis and independent prognostic factors for metastasis and mortality. However, their implications after R0 resection remain debated. Thus, we sought to identify genomic signatures of pancreatic neuroendocrine tumor disease-specific mortality and recurrence after surgery for curative intent. METHODS:...

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PMID: 39366850
DOI: 10.1016/j.surg.2024.06.064

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