Article
KRAS and DAXX/ATRX gene mutations are correlated with the clinicopathological features, advanced diseases, and poor prognosis in Chinese patients with pancreatic neuroendocrine tumors.
International journal of biological sciences - 1 Jan 2014
Yuan Fei, Shi Min, Ji Jun, Shi Hailong, Zhou Chenfei, Yu Yingyan, Liu Bingya, Zhu Zhenggang, Zhang Jun
Abstract excerpt
BACKGROUND AND AIM: Pancreatic neuroendocrine tumor (pNET) is a clinically rare and heterogeneous group of tumors; its pharmacogenetic characteristics are not fully understood. This study was designed to examine the relationship between key gene variations and disease development and prognosis among Chinese patients with pNET. METHODS: Various pNET associated genes such as DAXX/ATRX, KRAS, MEN1, PTEN, TSC2,...
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