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APRIL / BAFF upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis

3 Oct 2024

Abstract excerpt

Hunner-type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 patients with HIC. Next-generation RNA sequencing demonstrated abundant plasma cell infiltration with frequent light chain restriction in HIC-affected bladder tissue. Subsequent...

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PMID: 39360360
DOI: 10.1002/path.6353

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