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Article

Deciphering Anticoagulant Active Substances and Mechanisms in Guanxinjing Formula Through Phenotype-Anchored Hierarchical Strategy and Topological Network Analysis.

Archiv der Pharmazie - 1 Jan 2026

Luo Yuanlin, Jia Xiaozhuan, Ren Hai, Zhu Yue, Ren Can, Zhao Jiao, Xu Heng, Wang Yi, Zhao Lu, Yang Zhenzhong

Abstract excerpt

Anticoagulation is the cornerstone for preventing thrombosis in coronary heart disease patients with atrial fibrillation or a mechanical heart valve. Guanxinjing formula (GXJF) demonstrates anticoagulant effects, while its anticoagulant substances and mechanisms remain unclear. In this study, the chemical composition of GXJF was identified, establishing a chemical basis for the discovery of anticoagulant...

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PMID: 41518373
DOI: 10.1002/ardp.70181

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