Article
Wide circulation of type 1 vaccine-derived poliovirus strains in clinical specimens from suspected cases of poliomyelitis, their contacts and in wastewater in Madagascar since late 2020.
Virology - 1 Dec 2024
Raharinantoanina Jonhson, Joffret Marie-Line, Bessaud Maël, Rakoto Danielle Aurore Doll, Dussart Philippe, Lacoste Vincent, Razafindratsimandresy Richter
Abstract excerpt
Madagascar has faced three major outbreaks of vaccine-derived polioviruses (VDPVs) in recent decades, with VDPV type 1 reemerging in late 2020. Here, we report the molecular characterization of these cVDPV1 strains. WHO protocols were used for poliovirus detection in stool and wastewater samples. Molecular genotyping was based on the 5' non-coding (5'NC), VP1, and 3Dpol regions. From 2020 to 2022, 92 of 5690...
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