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Article

Screening of genes co-associated with osteoporosis and chronic HBV infection based on bioinformatics analysis and machine learning.

Frontiers in immunology - 1 Jan 2024

Yang Jia, Yang Weiguang, Hu Yue, Tong Linjian, Liu Rui, Liu Lice, Jiang Bei, Sun Zhiming

Abstract excerpt

Objective: To identify HBV-related genes (HRGs) implicated in osteoporosis (OP) pathogenesis and develop a diagnostic model for early OP detection in chronic HBV infection (CBI) patients. Methods: Five public sequencing datasets were collected from the GEO database. Gene differential expression and LASSO analyses identified genes linked to OP and CBI. Machine learning algorithms (random forests, support vector...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39351238
DOI: 10.3389/fimmu.2024.1472354
PMCID: PMC11439653

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