Article
CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice.
Nature communications - 30 Sept 2024
Zhang Xueguang, Huang Gelin, Jiang Ting, Meng Lanlan, Li Tongtong, Zhang Guohui, Wu Nan, Chen Xinyi, Zhao Bingwang, Li Nana, Wu Sixian, Guo Junceng, Zheng Rui, Ji Zhiliang, Xu Zhigang, Wang Zhenbo, Deng Dong, Tan Yueqiu, Xu Wenming
Abstract excerpt
Spermiogenesis, the complex transformation of haploid spermatids into mature spermatozoa, relies on precise spatiotemporal regulation of gene expression at the post-transcriptional level. The mechanisms underlying this critical process remain incompletely understood. Here, we identify centrosomal protein 112 (CEP112) as an essential regulator of mRNA translation during this critical developmental process....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.