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Article

Dissecting the Significance of Acid Phosphatase 1 Gene Alterations in Prostate Cancer.

JCO precision oncology - 1 Oct 2024

Abdallah Nour, Elliott Andrew, Smith Norm, Stanford Stephanie M, Agarwal Neeraj, Bagrodia Aditya, Garje Rohan, Bottini Nunzio, McKay Rana R

Abstract excerpt

PURPOSE: The acid phosphatase 1 (ACP1) gene encodes low-molecular-weight protein tyrosine phosphatase, which is overexpressed in prostate cancer (PC) and a potential therapeutic target. We analyzed ACP1 expression in primary/metastatic PC and its association with molecular profiles and clinical outcomes. METHODS: NextGen sequencing of DNA (592-gene/whole-exome sequencing)/RNA(whole-transcriptome sequencing) was...

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Identifiers

PMID: 39348661
DOI: 10.1200/PO-24-00444

Genes

ACP1
PC
TP53

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