Article
CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer.
Head & neck - 1 Feb 2025
Cui Zhibin, Kang Hyunseok, Li Hua, Lee Eliot D, Lee Yoon Se, Peterson Christopher N, Long Steven R, Grandis Jennifer R, Johnson Daniel E
Abstract excerpt
BACKGROUND: Human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an emerging epidemic and a subset of HPV-positive patients experience aggressive disease with metastases. The CYLD gene is frequently altered in HPV-positive HNSCC, but the role of these alterations in disease progression is poorly understood. METHODS: We identified 11 HPV-positive HNSCC patients with CYLD...
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