Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of wild type or a Q311E mutant MB21D2 promotes a pro-oncogenic phenotype in HNSCC.

Molecular oncology - 1 Dec 2020

Gracilla Daniel E, Korla Praveen Kumar, Lai Ming-Tsung, Chiang An-Jen, Liou Wen-Shiung, Sheu Jim Jinn-Chyuan

Abstract excerpt

Cadherin-mediated cell-cell contacts regulated by intracellular binders play critical roles in tissue homeostasis and tumorigenesis. Here, we screened mutational profiles of 312 annotated genes involved in cadherin binding in human squamous cell carcinomas and found MB21D2 to carry a unique recurrent Q311E mutation. MB21D2 overexpression was also frequently found in head and neck cancer (HNSCC) and was associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Head and Neck Neoplasms

Share to Spheroids, Cellular

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Stem Cell Assay

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 32979859
DOI: 10.1002/1878-0261.12806
PMCID: PMC7718949

Genes

MB21D2
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of wild type or a Q311E mutant MB21D2 promotes a pro-oncogenic phenotype in HNSCC.PMID 32979859Read ↗

Integrating bulk and single-cell RNA sequencing reveals<i>SH3D21</i>promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathwaySemantic proximity Read ↗

Selective requirement for Mediator MED23 in Ras-active lung cancerSemantic proximity Read ↗

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinomaSemantic proximity Read ↗

LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)Semantic proximity Read ↗

A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9Semantic proximity Read ↗

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.Semantic proximity Read ↗

JMJD2A predicts prognosis and regulates cell growth in human gastric cancerSemantic proximity Read ↗

MBIP promotes ESCC metastasis by activating MAPK pathwaySemantic proximity Read ↗

Aberrant overexpression of transcription factor Forkhead box D1 predicts poor prognosis and promotes cancer progression in HNSCCSemantic proximity Read ↗

Bromodomain Protein BRD4-Mediated Mutant p53 Transcription Promotes TNBC ProgressionSemantic proximity Read ↗

KIF21A influences breast cancer metastasis and survivalSemantic proximity Read ↗

CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.