Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients.

doi:10.1016/j.euroneuro.2017.03.012

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Article

Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jul 2017

Mas Sergi, Gassó Patricia, Torra Mercé, Bioque Miquel, Lobo Antonio, González-Pinto Ana, Olmeda Maria Soledad, Corripio Iluminada, Vieta Eduard, Castro-Fornieles Josefina, Rodriguez-Jimenez Roberto, Bobes Julio, Usall Judith, Llerena Adrián, Saiz-Ruiz Jerónimo, Bernardo Miguel, Lafuente Amalia, PEPs Group

Abstract excerpt

Risperidone (R) is the most prescribed antipsychotic drug for patients with a first episode of psychosis (FEP). In a naturalistic cohort of chronic psychiatric inpatients, we demonstrated that clinicians adjust R dosage by CYP2D6 activity, despite being blinded to the genotype, which we described as an "intuitive pharmacogenetic" process. The aim of the present study is to replicate our previous findings of...

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Identifiers

PMID: 28389049
DOI: 10.1016/j.euroneuro.2017.03.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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