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Article

Somatic mutation of targeted sequencing identifies risk stratification in advanced ovarian clear cell carcinoma.

Gynecologic oncology - 1 Dec 2024

Wan Shimeng, Gao Yang, Wu Sisi, Wang Hua, Tong Jiyu, Wei Wei, Ren Hang, Yang Danni, He Hao, Ye Hong, Cai Hongbing

Abstract excerpt

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a unique subtype of epithelial ovarian cancer. Advanced OCCC display a poor prognosis. Therefore, we aimed to make risk stratification for precise medicine. METHODS: We performed a large next generation sequencing (NGS) gene panel on 44 patients with OCCC in FIGO stage II-IV. Then, by machine learning algorithms, including extreme gradient boosting (XGBoost),...

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Share to Adenocarcinoma, Clear Cell
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

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Share to Neoplasm Staging

Share to Ovarian Neoplasms

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Source

Identifiers

PMID: 39342920
DOI: 10.1016/j.ygyno.2024.09.017

Genes

ATM
CTNNA1
KMT2A
MUC16
NOTCH3

Provenance

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