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Rational Design and Modification of NphB for Cannabinoids Biosynthesis.

Molecules (Basel, Switzerland) - 19 Sept 2024

Xia Wenhao, Liu Shimeng, Chu Huanyu, Chen Xianqing, Huang Lihui, Bai Tao, Jiao Xi, Wang Wen, Jiang Huifeng, Wang Xiao

Abstract excerpt

The rapidly growing field of cannabinoid research is gaining recognition for its impact in neuropsychopharmacology and mood regulation. However, prenyltransferase (NphB) (a key enzyme in cannabinoid precursor synthesis) still needs significant improvement in order to be usable in large-scale industrial applications due to low activity and limited product range. By rational design and high-throughput screening,...

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PMID: 39339449
DOI: 10.3390/molecules29184454
PMCID: PMC11434003

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