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Article

Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.

Journal of molecular biology - 12 Oct 2012

Shoyama Yoshinari, Tamada Taro, Kurihara Kazuo, Takeuchi Ayako, Taura Futoshi, Arai Shigeki, Blaber Michael, Shoyama Yukihiro, Morimoto Satoshi, Kuroki Ryota

Abstract excerpt

∆1-Tetrahydrocannabinolic acid (THCA) synthase catalyzes the oxidative cyclization of cannabigerolic acid (CBGA) into THCA, the precursor of the primary psychoactive agent ∆1-tetrahydrocannabinol in Cannabis sativa. The enzyme was overproduced in insect cells, purified, and crystallized in order...

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PMID: 22766313
DOI: 10.1016/j.jmb.2012.06.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22766313-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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