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SARS-CoV-2 Mutations Lead to a Decrease in the Number of Tissue-Specific MicroRNA-Binding Regions in the Lung.

Bulletin of experimental biology and medicine - 1 Feb 2023

Zhiyanov A P, Shkurnikov M Yu

Abstract excerpt

RNA interference in vertebrates acts as an antiviral mechanism only in undifferentiated embryonic stem cells and is mediated by microRNAs. In somatic cells, host microRNAs also bind to the genomes of RNA viruses, regulating their translation and replication. It has been shown that viral (+)RNA can evolve under the influence of host cell miRNAs. In more than two years of the pandemic, the SARS-CoV-2 virus has...

Topics

Humans
Alveolar Epithelial Cells
COVID-19
Host Microbial Interactions
Lung
MicroRNAs
Mutation
SARS-CoV-2

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36899205
DOI: 10.1007/s10517-023-05742-0
PMCID: PMC10005917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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