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Article

RRAGD variants cause cardiac dysfunction in a zebrafish model.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2024

Adella Anastasia, Tengku Faris, Arjona Francisco J, Broekman Sanne, de Vrieze Erik, van Wijk Erwin, Hoenderop Joost G J, de Baaij Jeroen H F

Abstract excerpt

The Ras-related GTP-binding protein D (RRAGD) gene plays a crucial role in cellular processes. Recently, RRAGD variants found in patients have been implicated in a novel disorder with kidney tubulopathy and dilated cardiomyopathy. Currently, the consequences of RRAGD variants at the organismal level are unknown. Therefore, this study investigated the impact of RRAGD variants on cardiac function using a zebrafish...

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Source

Identifiers

PMID: 39331021
DOI: 10.1152/ajpheart.00705.2023

Genes

RRAGD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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