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Article

Pravastatin Protects Cytotrophoblasts from Hyperglycemia-Induced Preeclampsia Phenotype.

Cells - 13 Sept 2024

Pantho Ahmed F, Mohamed Sara, Govande Janhavi V, Rane Riddhi, Vora Niraj, Kelso Kelsey R, Kuehl Thomas J, Lindheim Steven R, Uddin Mohammad N

Abstract excerpt

There are no effective therapies to prevent preeclampsia (PE). Pravastatin shows promise by attenuating processes associated with PE such as decreased cytotrophoblast (CTB) migration, aberrant angiogenesis, and increased oxidative stress. This study assesses the effects of pravastatin on hyperglycemia-induced CTB dysfunction. METHODS: Human CTB cells were treated with 100, 150, 200, 300, or 400 mg/dL glucose for...

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Identifiers

PMID: 39329718
DOI: 10.3390/cells13181534
PMCID: PMC11430553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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