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Article

Comprehensive Study on Central Precocious Puberty: Molecular and Clinical Analyses in 90 Patients

26 Sept 2024

Abstract excerpt

CONTEXT: Defects in MKRN3, DLK1, KISS1, and KISS1R and some disorders, such as Temple syndrome (TS14), cause central precocious puberty (CPP). Recently, pathogenic variants (PVs) in MECP2 have been reported to be associated with CPP. OBJECTIVE: We aimed to clarify the contribution of (epi)genetic abnormalities to CPP and clinical and hormonal features in each etiology. METHODS: We conducted targeted sequencing...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39324648
DOI: 10.1210/clinem/dgae666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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