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Prevalence and Reclassification of Genetic Variants in South African Populations with Breast Cancer.

Genes, chromosomes & cancer - 1 Sept 2024

Osler Tabitha S, Brandenburg Jean-Tristan, Schoeman Mardelle, Chen Wenlong Carl, Urban Michael F, Mathew Christopher G

Abstract excerpt

Concurrent testing of numerous genes for hereditary breast cancer (BC) is available but can result in management difficulties. We evaluated use of an expanded BC gene panel in women of diverse South African ancestries and assessed use of African genomic data to reclassify variants of uncertain significance (VUS). A total of 331 women of White, Black African, or Mixed Ancestry with BC had a 9-gene panel test, with...

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PMID: 39324485
DOI: 10.1002/gcc.23275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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