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Article

Incremental predictive value of genetic risk and functional brain connectivity in determining antipsychotic response in schizophrenia.

Psychiatry research - 1 Dec 2024

Mehta Urvakhsh Meherwan, Roy Neelabja, Bahuguna Ashutosh, Kotambail Ananthapadmanabha, Arunachal Gautham, Venkatasubramanian Ganesan, Thirthalli Jagadisha

Abstract excerpt

We aimed to assess the incremental value of schizophrenia polygenic risk score (PgRS) and resting-state functional brain connectivity (rsFC) when added to clinical data in predicting the six-week response to oral risperidone (Risperdal) in schizophrenia. Fifty-seven, 54, and 43 individuals in a group of never-before-treated first-episode schizophrenia had good quality whole-genome sequencing (10x), rsFC, and both...

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PMID: 39321637
DOI: 10.1016/j.psychres.2024.116201

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