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Article

CsgA gatekeeper residues control nucleation but not stability of functional amyloid.

Protein science : a publication of the Protein Society - 1 Oct 2024

Olsen William P, Courtade Gaston, Peña-Díaz Samuel, Nagaraj Madhu, Sønderby Thorbjørn V, Mulder Frans A A, Malle Mette G, Otzen Daniel E

Abstract excerpt

Functional amyloids, beneficial to the organism producing them, are found throughout life, from bacteria to humans. While disease-related amyloids form by uncontrolled aggregation, the fibrillation of functional amyloid is regulated by complex cellular machinery and optimized sequences, including so-called gatekeeper residues such as Asp. However, the molecular basis for this regulation remains unclear. Here we...

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PMID: 39302107
DOI: 10.1002/pro.5178
PMCID: PMC11414021

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