Article
Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.
mBio - 17 Jul 2018
Klein Roger D, Shu Qin, Cusumano Zachary T, Nagamatsu Kanna, Gualberto Nathaniel C, Lynch Aaron J L, Wu Chao, Wang Wenjie, Jain Neha, Pinkner Jerome S, Amarasinghe Gaya K, Hultgren Scott J, Frieden Carl, Chapman Matthew R
Abstract excerpt
Curli amyloid fibers are produced as part of the extracellular biofilm matrix and are composed primarily of the major structural subunit CsgA. The CsgE chaperone facilitates the secretion of CsgA through CsgG by forming a cap at the base of the nonameric CsgG outer membrane pore. We elucidated a series of finely tuned nonpolar and charge-charge interactions that facilitate the oligomerization of CsgE and its...
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