Article
Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin.
Scientific reports - 13 Jan 2021
Bishop David P, Westerhausen Mika T, Barthelemy Florian, Lockwood Thomas, Cole Nerida, Gibbs Elizabeth M, Crosbie Rachelle H, Nelson Stanley F, Miceli M Carrie, Doble Philip A, Wanagat Jonathan
Abstract excerpt
Emerging and promising therapeutic interventions for Duchenne muscular dystrophy (DMD) are confounded by the challenges of quantifying dystrophin. Current approaches have poor precision, require large amounts of tissue, and are difficult to standardize. This paper presents an immuno-mass spectrometry imaging method using gadolinium (Gd)-labeled anti-dystrophin antibodies and laser ablation-inductively coupled...
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