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Article

Chimeric vaccine based on Iraqi HLA alleles against a predominant local Escherichia coli phylogroup.

Frontiers in immunology - 1 Jan 2026

Koro Aziz Tamo, Altaii Hiyam Adil

Abstract excerpt

Introduction: Escherichia coli remains amongst the most globally important pathogens implicated in severe clinical manifestations. The progressive rise in multidrug-resistant strains highlights the urgent need for new vaccines. Therefore, this study was designed to develop a new multi-epitope vaccine containing the most conserved epitopes across E. coli pathotypes. Consequently, the study aimed to investigate the...

Read the complete abstract on PubMed

Topics

Animals
Escherichia coli
Mice
HLA Antigens
Escherichia coli Infections
Fecal Microbiota Transplantation
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alleles

Escherichia coli Vaccines

Epitopes, T-Lymphocyte

Female

Iraq

Epitopes, B-Lymphocyte

Protein Subunit Vaccines

Escherichia coli Proteins

Antibodies, Bacterial

Phylogeny

Adjuvants, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 42682736
DOI: 10.3389/fimmu.2026.1875830
PMCID: PMC13529670

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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