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Article

Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2024

Jensen Jeffrey L, Bobek Olivia, Chan Irenaeus C C, Miller Brian C, Hillman David W, Heller Glenn, Druley Todd, Armstrong Andrew J, Morris Michael J, Milowsky Matthew I, Beltran Himisha, Bolton Kelly L, Coombs Catherine C

Abstract excerpt

PURPOSE: Mutations in hematopoietic progenitor cells accumulate with age leading to clonal expansion, termed clonal hematopoiesis (CH). CH in the general population is associated with hematopoietic neoplasms and reduced overall survival (OS), predominantly through cardiovascular adverse events (CVAE). Because androgen receptor pathway inhibitors (ARPI) used in metastatic castration-resistant prostate cancer...

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Androgen Receptor Antagonists
Androstenes
Clonal Hematopoiesis
Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progression-Free Survival

Prostatic Neoplasms, Castration-Resistant

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Open in PubMed Open full text

Identifiers

PMID: 39287426
DOI: 10.1158/1078-0432.CCR-24-0803
PMCID: PMC11539927

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TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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