Article
Predictive value of TP53 RNAscope®in situ hybridization and p53 immunohistochemistry for TP53 mutational status in canine diffuse large B-cell lymphoma.
The veterinary quarterly - 1 Dec 2024
Foiani Greta, Licenziato Luca, Marconato Laura, Fanelli Antonella, Melchiotti Erica, Zanardello Claudia, Aresu Luca, Vascellari Marta
Abstract excerpt
TP53 mutations are associated with short survival and poor treatment response in canine diffuse large B-cell lymphoma (cDLBCL). The expression of TP53 by RNAscope® in situ hybridization and p53 by immunohistochemistry (IHC) was investigated in 37 formalin-fixed paraffin-embedded cDLBCL, to assess their correlation with TP53 mutational status and to evaluate their prognostic value. TP53 was detected in all samples...
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