Enriching productive mutational paths accelerates enzyme evolution.

Abstract excerpt

Darwinian evolution has given rise to all the enzymes that enable life on Earth. Mimicking natural selection, scientists have learned to tailor these biocatalysts through recursive cycles of mutation, selection and amplification, often relying on screening large protein libraries to productively modulate the complex interplay between protein structure, dynamics and function. Here we show that by removing...

Topics

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• Biocatalysis
• Directed Molecular Evolution
• Enzymes
• Evolution, Molecular
• Models, Molecular